Abstract : <p>Parenting a child with ASD is very demanding. the nature of the diagnosis, child behavior, sign and symptoms of ASD, financial burden and parental isolation putting parents at risk for developing PTSD while perceived social support might decrease their risks. The purposes of this study were to explore predictors of risk of PTSD among parents of child with ASD and checking the moderation effect of social support between gender and risk of PTSD. Quantitative cross-sectional descriptive &ndash; correlation design including 142 parents covering all centers in Amman was applied. Post-Traumatic Stress Disorder Checklist for Diagnostic Statistical Manual 5 (PCL-5), Multidimensional Scale of Perceived Social Support (MSPSS) and socio-demographics checklist were used in this study. Parents of children with ASD were at high risk of PTSD. Being a mother, the lowest perceived social support, those who pay for the treatment, the longest time since diagnosis and severity of the diagnosis predicted higher parental risk of PTSD while perceived social support moderates the relationship between gender and risk of PTSD. Findings emerged from this study allow nurses to understand and priorities the reasons of PTSD and will help them to develop appropriate nursing care plans. Moreover, a supportive program to the parents, especially mothers is needed. This supportive program should include informational support, financial support and social support. The effect of these programs can be evaluated through interventional studies in the future. Parenting a child with ASD is very demanding. the nature of the diagnosis, child behavior, sign and symptoms of ASD, financial burden and parental isolation putting parents at risk for developing PTSD while perceived social support might decrease their risks. The purposes of this study were to explore predictors of risk of PTSD among parents of child with ASD and checking the moderation effect of social support between gender and risk of PTSD. Quantitative cross-sectional descriptive &ndash; correlation design including 142 parents covering all centers in Amman was applied. Post-Traumatic Stress Disorder Checklist for Diagnostic Statistical Manual 5 (PCL-5), Multidimensional Scale of Perceived Social Support (MSPSS) and socio-demographics checklist were used in this study. Parents of children with ASD were at high risk of PTSD. Being a mother, the lowest perceived social support, those who pay for the treatment, the longest time since diagnosis and severity of the diagnosis predicted higher parental risk of PTSD while perceived social support moderates the relationship between gender and risk of PTSD. Findings emerged from this study allow nurses to understand and priorities the reasons of PTSD and will help them to develop appropriate nursing care plans. Moreover, a supportive program to the parents, especially mothers is needed. This supportive program should include informational support, financial support and social support. The effect of these programs can be evaluated through interventional studies in the future</p>