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Abstract : Polycystic ovarian syndrome (PCOS) is characterized by increased ovarian angiogenesis and vascularity. Vascular endothelial growth factor (VEGF) is main angiogenic factor which increased in PCOS and may play an important role in these vascular changes. Placental growth factor (PlGF), a VEGF family member. PlGF and VEGFA that are expressed by both granulosa cells and theca cells, are required for ovulation, luteinization, and follicular angiogenesis. Considering potential roles of PlGF and its receptor (sflt-1) in ovarian function and embryo implantation, in the present study, the association of these factors with ICSI outcome among PCOS women during controlled ovarian stimulation have evaluated. This comparative cross sectional study include of 30 PCOS women (Rotterdam criteria) and matched 30 non- PCOS women undergoing controlled ovarian stimulation. Serum was collected on day 3 and day of oocyte retrieval. Follicular fluid (FF) was collected on retrieval day. PlGF and sFlt-1 concentrations were measured using ELISA. In the present study, at the measured time point of controlled ovarian stimulation the result observed no significant difference in the serum PlGF and sFlt levels between PCOS women compared with non PCOS women (p<0.001). As well as the FF PlGF was correlated positively with total number of oocyte retrieved, number of MII oocyte and the ovarian reserve marker antimullerian hormone (AMH) but it was correlated negatively with basal FSH level. PlGF bioavailability in FF was significantly greater in PCOS women compared with non-PCOS (p < 0.001). These data provide evidence that FF PlGF was correlated with ovarian stimulation and ICSI outcome. Moreover, its level is significantly increased in women with PCOs undergoing controlled ovarian stimulation. Thus that PlGF may be played a role in PCOs pathogenesis and its angiogenic dysregulation.

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