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Abstract : To investigate the Efficacy of propolis in the healing of cutaneous wounds of rabbits is studied on the basis of histopathological changes; Morphometric evaluations. The study was done at the Department of Oral and Maxillofacial Surgery, Dentistry College, Mosul University, this research included 25 domestic male rabbits1- 1.5 kg body weight and 1-2 years of age. The animals were divided into 2 groups, each animal, full-thickness skin wounds 3cm*3cm in diameter were created. One wound on each animal served as a control, the second wound on each animal propolis was applied daily, The wounds were investigated histopathological changes for wound healing after 3, 7, 14, 15, and 28 days. The data were obtained from the digital imaging analyses of wounds in the rabbit. There was no significant (p<0.05) between propolis-treated wounds and control wounds on day 7; wound area in propolis-treated, and control wounds on day 14; Within the healthy group, there were no significant differences in the propolis wound area on day 7, epithelization area on day 14; day 21and day 28. Within the propolis group, there were no significant differences in any of the evaluated parameters at any time point.so the wound site for group A1 with re-epithelialization (Score 3), creation of scar tissue constituted of mature fibrous tissue, angiogenesis with numerous blood vessels, and no inflammatory cell infiltration (score 0). Complete re-epithelialization (Score 4), creation of scar tissue, composed of mature fibrous tissue, angiogenesis with numerous blood vessels, and no infiltration of inflammatory cells were observed using H&E staining at 100X and 400X. (score 0). 100X, 400X H&E stain for group A2.also on days 14 (P-value=0.0293 *), 21 (P-value=0.767), and 28 (P-value= 1.00), significant scores of granulation tissue of rabbit skin wound healing process were found in propolis group A2 (P-value=0.0069 **) compared to the control group A1 (P-value=0.0074 **).

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