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Abstract : Type 1 diabetes mellitus (T1DM) is a chronic, immune-mediated disease characterized by the destruction of insulin-producing β cells in the pancreas. This study investigated the influence of single nucleotide polymorphisms (SNP) in gene of macrophage migration inhibitory factor (MIF), -173 G > C (rs755622), on T1DM patients. The study was included 75 T1DM patients and 25 healthy subjects. The-173 G / C SNP MIF gene was detected by using tetra-primer amplification refractory mutation system (ARMS) in T1DM patients and controls. The genotype distribution results of the -173G/C SNP of MIF gene showed significant difference (p<0.05) between controls (GG: n= 25, 100%; GC: n=0, 0%; CC: n=0, 0%) and T1DM patients (GG: n= 42, 56%; GC: n=25, 33.33%; CC: n=8, 10.67%). These results showed an increased in GC, CC genotype and C allele of the -173G/C in T1DM patients than controls, and they were significantly more likely than controls to have the mutant allele C (OR=1.881, 95%CI=0.213-16.585, p=0.564). These results indicate a possible role for the C allele in T1DM disease. The present study suggested that the -173G/C SNP in the MIF gene statistically association (p<0.05) with the risk of T1DM occurrence in Iraqi patients.

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