Coronavirus disease 2019 (COVID-19) is a worldwide epidemic generated by the severe acute respiratory syndrome coronavirus 2 coronavirus ((SARS-CoV-2)). The cell entry system of COVID-19 is stimulated by the viral spike protein bonded to the angiotensin-converting enzyme 2 receptor. Adipokines' actions contribute to infection pathogenesis. The researchers wanted to look at levels of chemerin and omentin in COVID19 patients, including linkage among both adipokine, the severity of disease (mild, severe, critical). Chemerin and omentin are reported to have inflammatory and metabolic effects, and have been implicated in the development of chronic diseases. However, results are still limited regarding role of chemerin in chronic diseases. Chemerin and omentin in COVID19 patients suggest that these adipokines have a role in influencing disease severity. Chemerin and omentin are reported to have inflammatory and metabolic effects, and have been implicated in the development of chronic diseases. However, results are still limited regarding the role of chemerin in chronic diseases. Our study focused on Chemerin, and Omentin levels in COVID-19 patients to demonstrate a roles in influencing disease severity. This is a case-control study design consisting of COVID-19 patients before any treatment was recruited from the Intensive Care Unit hospitalization ICU department of the AL-Amal Hospital in AL-Najaf City, Iraq compared with apparently healthy volunteers as control group. The patients were divided into three groups: mild/moderate, severe, and critically ill cases. The enzyme-linked immunosorbent assay (ELISA) kit used to measure plasma chemerin and Omentin levels in all patient groups. COVID-19 patients' clinical symptoms, diagnostic tests, and outcomes were studied chronologically. Serum chemerin was significantly increased in COVID-19 patients but Omentin concentrations was significantly decreased compared to healthy volunteers (2.1± 0.48 and 5.65± 2.7;P < 0.05 vs. 1.36± 0.49 and 11.43± 2.42; (P < 0.050) respectively). The serum chemerin was significantly higher but and Omentin levels was significantly lower in critically ill patients than that in severe patients cases (P < 0.00010). Circulating chemerin and omentin levels are early predicators markers It has been linked to the severity of COVID-19 disease, may be risk of death in COVID-19 patients.