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Abstract : Late microvascular problems such retinopathy, neuropathy, and diabetic nephropathy are frequently brought on by uncompensated chronic hyperglycemia. In the pathophysiology of diabetes mellitus, the vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are of critical importance. The aim of this study to assessment level of VEGFA and VEGFR-2 in a group of patients with un-controlled type 2 diabetes mellitus (T2DM) and compare it with apparently healthy non diabetic subjects and study the correlation with other factors. There were 180 participants in the research study,70 control persons and 110 T2DM patients. Glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) values were calculated in order to evaluate glycemic management. In addition, serum cholesterol, triglyceride, HDL and LDL were calculated by COBAS INTEGRA 400 plus. VEGF-A, VEGFR-2 levels were estimated using enzyme-linked immunosorbent assay(ELISA) kit. The levels of VEGF-A and VEGFR2 in the patients group and in the normal control found to differ significantly (p < 0.001). Significant positive correlation was seen between the level of VEGF-A and glucose, duration of disease. Weak non-significant positive correlation was also found between VEGFR2 and serum glucose (p=0.09). Patients with uncontrolled diabetes produce VEGF-A and its receptor 2 concentrations that are comparable to those of apparently healthy people, which may be a sign that insufficient glucose management accelerates the development of vascular problems. The absence of correlation between VEGF-A, VEGFR2 and lipid abnormalities demonstrate that lipid problems related to diabetes could not affect how angiogenesis is regulated.

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