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Abstract : New ligand was synthesized as Mannich base containing 1,3,4-Oxadiaole ring and characterized by FT-IR,UV, Elemental analysis, 1HNMR and 13CNMR. Then a complexes of Pt+4 and Cu+2 were synthesized by complexation with prepared ligand and characterized by UV, FT-IR, flame atomic absorption Magnetic susceptibility and molar conductivity. The results approved success of synthesis procedure. The antibacterial activity and cytotoxicity assay were tested for the ligand and their metal complexes. The result show the complexes active compound as antibacterial and antifungal against bacterium Escherichia coli(gram negative) and Staphylococcus aurous (gram positive) also against fungi Candida albicans and Aspergillus flavus. Cytotoxicity tested on normal cell line (MDCK) and the results showed that LD50 of L = 936 µg/ml, toxicity of Pt = 875 µg/ml and toxicity of Cu = 1356 µg/ml. Toxicity also tested for the ligand and both complexes against Human lung cancer cell line, the results showed that LD50 of Pt complex = 615 µg/ml, toxicity of Cu complex = 653 µg/ml and toxicity of free ligand = 620 µg/ml. Low MIC was resulted for the ligand and both complexes compared with Amoxicillin and Ampicillin as antibiotic.

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