When blood or plasma is transferred from the unit car to the blood donor unit using a conventional cooler box without any tools to keep the vibration effect down, it is very possible for a decrease in blood quality to occur. An examination is carried out to determine the quality of blood through routine hematological examinations by counting the number of red blood cells and platelets. The purpose of this study was to determine the impact of vibration on the number of red blood cells and thrombocytes. The research design was a pre- and post-test with a control group. The sample size for each group was ten tubes of blood. Differences in the number of erythrocytes and platelets were processed by one way ANOVA and Tukey's HSD test. The Wilcoxon test was used to compare the morphology of erythrocytes and platelets. It has been found that there was a significant difference in the number of erythrocytes between the group that was vibrated at a frequency of 10 Hz and the group that was vibrated at a frequency of 0 Hz and 5 Hz, with p values of 0.00 and 0.00, respectively. There was a significant difference in the number of platelets between the groups that were vibrated with a frequency of 10 HZ compared to the groups that were vibrated with a frequency of 0 HZ and 5 HZ, with p values of 0.003 and 0.022. It is recommended that in the process of transporting blood bags from the location of the mobile unit to UDD, excessive vibration be avoided to maintain blood quality.