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Abstract : Type 2 diabetes is a multifactorial disease and due to a combination of genetic and environmental risk factors. The paper aims to investigate serum preptin, and insulin like growth factor 2 receptor and their role in T2DM patients in a Kirkuk population. The hospital-based cases- control study was conducted for patients with Type 2 diabetes patients that attended of the Diabetic center in K1 Hospital and Consultation Clinic of Kirkuk, and Azadi Teaching Hospital in Kirkuk during the period from March 2021– August 2021 A total of 150 subjects were screened for concentration of preptin, and insulin like growth factor 2 receptor (IGF2R), glucose, and whole blood was estimated for glycated hemoglobin (HbA1C) especially in relation to (age, and gender) from all patients were recorded. Among the Type 2 diabetes patients recruited for this study, serum glucose fasting blood sugar concentration which showed that T2DM patients had average 168.16± 32.69 mg/dl was significantly higher than in control subjects, p < .001, and for HbA1C the average of T2DM patients whose had 9.87± 2.08 % was also significantly different from control group, p < 0.001. preptin levels that the majority of patients with T2DM had the mean of (66.79± 46.67 pg/ml) that was significantly higher than the mean for control group (17.27± 4.05 pg/ml).U = 4759, p < .001. According to IGF_2R levels revealed that the mean for T2DM patients (23.20± 10.95μg/ml) was significantly higher than the mean for control group (5.98± 3.90 μg/ml), U = 4747.5, p < .001. Greater preptin concentrations in recently identified in T2DM subjects recommended that preptin may performance a role in Type 2 Diabetes Millets causation. Soluble IGF2R could directly affect susceptibility to type 2diabetes that influence insulin resistance.

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