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Abstract : Two simple study in this research sensitive, rapid and unexpansive are schiff’s base and oxidative coupling reaction for determination of Amlodipine Besylate (AML) ether in pure form or in it’s tablets. The methods were: (I) Synthesis of a Schiff's base (in basic medium) between (AML) and Benzaldehyde, this form a yellow product which has the highest absorption at λmax (383 nm). (II) Oxidative coupling reaction between (AML) and Phenylhydrazine in basic medium to form yellow product of absorbace at λmax (364 nm). Beer's law is obeyed from (10-165) µg/ml with a molar absorptivity (1.91×105) L/mole.cm. and the limit of detection is (0.02) µg/ml for the first method and (5-150) µg/ml with a molar absorptivity (1.59×105) L/mole.cm. and the limit of detection is (0.02) µg/ml for the second method. In this proposed methods were successfully applied to the determination of (AML) in pure form and in pharmaceutical preprations.

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