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Abstract : The purpose of this study was to develop novel dissolving microneedle (MN) arrays fabricated from hyaluronic acid (HA) as a material and to estimate the effect of hyaluronic acid concentration, molecular weight, amount of loaded drug and on the mechanical properties of MN arrays. In this study, a model drug that belongs to BCS class IV with decreased water solubility and permeability through the skin. MN arrays mechanical strength was increased by increasing the molecular weight. indicating that they could puncture the skin and create drug permeation pathways successfully. Dissolution properties and the effect of the presence of tween 80 in the formulation also was estimated in this research. PH of the polymeric MNs solution was found to be 7.4 indicating the ability of using the MNs over the skin without causing irritation. Reduced concentration of the drug affected the mechanical strength of MNs positively. These findings indicated that using novel MN arrays fabricated from hyaluronic acid (HA) is a very useful and effective strategy to improve the transdermal delivery of drugs.

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