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Abstract : This study was conducted to investigate the adverse effect of narcotic drugs (stimulants and depressor) used by addicts by take blood and biochemical parameters which include Liver Function (AST, ALT, ALP and Bilirubin ) also for kidney functions test that include urea and creatinine B. urea, Creatinine. The present study focused on a comparative investigation of the biochemical and histological effects of narcotic substances in vivo on albino mice Mus muscular Second part from study (84) Blood samples were collected from albino mice they exposure for different dose of pseudoephedrine and tramadol (low, Moderate and high) For 12 weeks (experiment group) under different temperatures. Twenty one (21) dosed tramadol under 40C and other 21 dosed tramadol under 10C.in another hand 21 of mice dosed pseudoephedrine under 40C and 21 dosed pseudoephedrine in 10C. (20) blood sample of mice who don't exposure for narcotics only distal water (control group).Ten (10) mice under 40c and 10 mice under 10C.The results indicated significant difference in biochemical parameters, there was a significant increase (P < 0.05) in the levels of Aspartate amino Transferase (AST), Alanine amino Transferase (ALT), Alkaline Phosphatase (ALP) and Bilirubin in experimental group when compared with control group. Also it was showed a significant increase (P < 0.05) in the levels of serum creatinine and blood urea compared with control group.

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