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Abstract : Pistacia khinjuk is a plant that has long been utilized in common medicine to cure a variety of conditions. The aim of this study was to evaluate that Pistacia khinjuk fruit extract affected several biochemical markers in a rat model to examine whether it might be used in traditional medicine. The hydroalcoholic extract was prepared by air-drying the plant's fruits. A total of forty male rats were separated into eight groups, with one serving as a control group and the others as test groups. The test animals were given orally for twenty-eight days a 200 mg/kg dose of Pistacia khinjuk for group2, Sorafenib for group3, Alcoholic extract and Sorafenib for group4, CCl4 for group5, Alcoholic extract and CCl4 for group6, Sorafenib and CCl4 for group7, and Alcoholic extract, Sorafenib, and CCl4 group8. The biochemical data were analyzed with SPSS software and represented as means ± SD before being submitted to one-way analysis of variance (ANOVA) and post-hoc Tukey tests. PNO2 and GSH levels fell significantly (p <0.05) in the CCl4 group compared to the control group, according to the results obtained for the specified biochemical parameters. When comparing the CCl4 group to the other groups, the levels of AFP and MDA rose considerably (p <0.05). The fruit extract of Pistacia khinjuk exhibits hypocholesterolaemic qualities, a hepatoprotective impact, enhances GSH, PNO2, and decreases MDA, according to this study. hepatic disorders may all benefit greatly from this treatment.

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