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Abstract : Cardiovascular disease (CVD) is a non - communicable disease chronic disease that is one of the leading causes of death and disability. CVD incidents are becoming more common over the world. Atherosclerosis is the leading cause of CVD, which encompasses coronary heart disease, vascular disease, rheumatic heart disease, heart attack (MI), stable angina (SA), unstable angina (UA), as well as other disorders, according to the World Health (WHO). A total of 50 samples were used in this investigation, with 20 samples from the treatment group and 30 samples of patients with cardiovascular disorders. The levels of urea, creatinine, and osteonectin were measured in individuals with cardiovascular disease as well as a control group. That research reveals a link between osteonectin with age, as well as creatinine. Inside the current investigation, individuals with cardiovascular illnesses had a significant (p<0.05) increase in urea, creatinine, and osteonectin concentrations when compared with the control group. In addition, researchers discovered a link among osteonectin with age, and also creatinine, in individuals with cardiovascular disease. This study showed that patients suffering cardiovascular disorders have higher levels of bone biomarkers (osteonectin) and that cardiovascular diseases have an effect on kidney function.

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