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Abstract : Corona Virus Disease 2019 (COVID-19) globally a main healthcare threat, so it is important to understanding the role of humoral and cellular immune response in this disease. Follow up memory markers expression of T cell (CD3+CD45RO+CD62L+) and B cell (CD19+CD27+) in COVID-19 recovered patients for six months and correlation the level expression markers of memory T and B cell with severity. Also how long memory cell remained to provide protection against re-infection in COVID 19 recovery patients. The nasopharyngeal swab was use to confirm recovery via Real-Time Polymerase Chain Reaction (RT-PCR) technique. Cluster of Differentiation (CD) marker of memory cell count in peripheral blood via flowcytometry technique. Highest percent of COVID-19 recovered patients age groups is age group 30-39 (31.4%), Male have highest percent cases (62.9%) than female (37.1%). A significant decrease in CD3 P=0.0001 (P≤0.05) in studied recovered patients groups (G1, G2, G3 & G4) as compared with control group. In addition there is a significant differences within studied groups. A significant differences in CD3+CD45RO+, CD3+CD45RO+CD62L+ cell P=0.033, P=0.004 (P≤0.01) in studied groups as compared with control group. Finally, there is a significant differences P=0.001, P=0.024 (P≤0.05) between severity sub groups in G1, G2. Regarding B cell markers CD19, a significant increase P=0.021(P≤0.05) in studied recovered patients groups (G1, G2, G3 & G4) as compared with control group, also a significant differences within studied groups. A significant increase P=0.010 (P≤0.05) in CD19+Cd27+ of studied groups (G1, G2, G3 & G4) as compared with control group. Finally, a significant differences P=0.0001 (P≤0.01) between severity sub groups in G1, G2, G3 and G4. There were decreases CD3+ cell in recently COVID-19 recovered patients other markers CD45RO+ CD62L+ on CD3+ cell shown increase in peripheral blood T cell of COVID-19 recovered patients. Increase in the number of CD19+D27+ B cells. In addition CD3+ cell and CD19+ cell is correlated with COVID-19 severity.

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