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Abstract : Granular cell tumour (GCT) is a rare tumour that can occur anywhere in the body. The tongue is the most frequent anatomical site of origin, preceded by soft tissues. It is most frequent in 30 to 50 years old females, particularly of African-American ethnicity. This tumour often seems to occur as a firm to hard, non-tender lump that is well confined and unfixed to the surrounding tissues. The tumour almost always occur as a single lesion, but in 5.4 to 17.6 % of patients, presented as more than one lesions. Breast GCTs are formed in intra-lobular mammary connective tissue. Its frequent occurence in upper inner quadrant of the breast reflects the course of the supra-clavicular nerve and the cell of origin of this tumor is considered to be the schwann cells. S-100 protein is highly positive in tumour cells while negative expression is noticed for epithelial membrane antigen, mucin and cytokeratin staining. While the most of GCTs are benign, there have been a few reports of malignant instances (less than 1% of all GCTs, including breast lesions, are cancerous). GCTs can resemble breast cancer on mammography and on clinical examination. Hence, it is important to consider GCT in the differential diagnosis of both malignant and benign breast lesions. We present here a rare case of GCT of the breast in a 62 year old patient alogn with a breif review of literature with an emphasis on the diagnostic characteristics.

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