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Abstract : The condition known as polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, low-grade chronic inflammation, and ovarian dysfunction. Insulin resistance, obesity, abnormal glucose tolerance, and lipid abnormalities are examples of metabolic changes. In PCOS, there is an immune cell balance issue. Pentraxin 3 Another member of the pentraxin superfamily and an acute-phase protein, (PTX3) is essential for humoral innate immunity. adiposity and cardiovascular problems in PCOS-affected women are related to innate and adaptive immunological response. However, The level of circulating PTX3 in PCOS is still unknown. To assessment, circulating level of PTX3 in PCOS women, and find possible correlation between metabolic and hormonal consequences factors that could effect on serum PTX3 level. Serum levels of pentraxin 3 (PTX3), and fasting insulin (FINS), and hormones were measured by ELISA technique. Homeostatic model assessment of insulin resistance (HOMA-IR) and body mass index (BMI) were measured. Serum PTX3, Insulin levels, as well as HOMA-IR, LH, FSH, and LH/FSH were higher in PCOS women than in healthy women group. There were significantly positive correlations between PTX3level and BMI, WHR, FINS, and HOMA-IR. While, negative correlation with FSH, and SHBG, HDL-C levels in PCOS women group. Our findings demonstrate that the elevated levels of PTX3 seen in young PCOS women, as well as PTX3's independent association with hyperandrogenism and other endocrine and ovarian features of PCOS, are linked to obesity, cardiovascular issues, fibroblast dysfunction, and endothelial cell dysfunction in Pcos women.

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