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Abstract : Prostate cancer is one of the most common tumors in men worldwide, regardless of ethnic origin or demographics. It is the fifth leading cause of cancer death in men worldwide. In Africa, the disease ranks first in terms of incidence and mortality. What's more, in Morocco, the average age of prostate cancer patients is between 68 and 73. Among the many risk factors for prostate cancer, several studies have shown that specific genetic variants and viral implications are important factors in the initiation or development of prostate tumors. Recent studies have suggested that infection with EBV and HPV may also contribute to the development of this disease. However, the mechanisms by which these viruses may contribute to the development of prostate cancer are not yet fully understood. The aim of this study was to evaluate the potential role of co-infection with human papillomavirus (HPV) and Epstein-Barr virus (EBV) and their correlation with clinical and pathological parameters of prostate cancer. To achieve the objectives of these studies, a total of 100 blood samples were taken from Moroccan men with prostate cancer, after obtaining the necessary authorizations from the scientific research ethics committee. All clinical and pathological data were recorded. Extraction of genetic material according to the required protocol. The DNA samples obtained were stored for the viral applications mentioned below. A series of polymerase chain reactions and statistical analysis procedures were successfully performed. The potential viral influence on prostate cancer, previously proposed in other populations, was explored in Moroccan men. The results presented provide an overview of the main viral functions in prostate cancer in Moroccan men, and highlight the possibility of analyzing their clinical significance.

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