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Abstract : This study endeavors to appraise invulnerable particles CD45, CD74, cytokines TNF- B and IL-8 in patients infected with hepatitis B virus. An aggregate of (150) seropositive serum samples from patients infected with hepatitis B virus (HBV). Serum samples tested by ELISA assay to evaluate the concentration of cytokines and immune marks. Results showed that acute cases of disease express high level of cytokine and immune marks as compared with chronic and asymptomatic infection. Our study provided that acute hepatitis B Virus Infection causes high Immunological changes as compare with asymptomatic disease.

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