COVID-19 diseases due to the SARS-Cov-2 virus have become a global infectious disease. It is, therefore, crucial to investigate biomarkers that are involved in the pathogenicity and severity of the disease. This study aimed to investigate some immune-inflammatory and pathological biomarkers s during COVID-19 diseases. After providing written consent, 5 ml blood samples were drawn from 121 COVID-19 patients confirmed by Real Time Polymerase Chain Reaction (RT-PCR), including 77 Male and 44 Female COVID-19 cases with 52.64 years of mean age. Clinical analysis was performed including White blood cells (WBC), Lymphocytes (Lymph), D-dimer, Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), Ferritin, creatinine, urea and blood glucose were analysed after adjusting for sex, presence of comorbidity, weight and smoking status. Elevation of some clinical parameters was elevated in severe COVI D-19 patients compared to mild patients, also female COVID-19 patients had higher WBC and ferritin level compared to male patients. It can be concluded that some clinical biomarkers in COVID-19 patients, such as WBC, lymph percent, D-Dimer, Ferritin, ESR, CRP urea, and creatinine, are distinct predictive indicators for severe male COVID-19 patients, which are more frequent than opposite-sex gender.