Abstract : <p>Curcuma longa is a popular spice in Southern Asia and the Middle East. It has a long history of ethnopharmacological use for antibacterial, anti-inflammatory, antioxidant, and other properties. While the vitamin E family&#39;s tocotrienols have received a lot of attention in recent years due to their multi-targeted biological features, several studies are under underway to find compounds that can enhance the synergistic effects of curcumin and tocotrienols. The purpose of this research was to see if Cur and Toc could protect rats from monosodium Iodoacetate-induced arthritis (OA). Six groups of forty-two rats were formed at random. The volume of joint edema and the fatigue index of the gastrocnemius muscle were measured. Antioxidant enzymes and the amount of lipid peroxidation were also examined. By reducing ankle edema, the combination was found to dramatically lower the severity of arthritis. The antioxidant enzymes in the blood have greatly enhanced. Therefore, the combination of curcumin and tocotrienol resulted in a significant anti-oxidant and anti-inflammatory effect on induced arthritis.</p>