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Abstract : Polycystic ovarian syndrome (PCOS) is the most frequent endocrine disorder affecting Iraqi women of reproductive age. PCOS has been linked to autoimmune diseases, therefore the study's goal is to comparative the levels of interleukins (IL-17, IL-18, IL-22) among Iraqi women with autoimmune thyroid disease and PCOS. Collected about 90 serum samples from groups study (group of PCOS) (30 samples); group of thyroid disease (30 samples, as well as group of healthy women fertile (30samples) as control during the period (April – November) 2021 from many hospitals in Baghdad- Iraq. And determination levels of interleukins (IL-17, IL-18, IL-22) by quantitative sandwich enzyme immunoassay technique (Cusabio- China). Results of current study showed highest (Mean ±Std.) of IL-17 (101.17±19.80) of (≤30 -39) age group and (106.63±15.72) of (40- ≥50) age group, so higher levels of IL-18 (137.06±25.53) and IL-22(36.44±10.05) were among Thyroiditis group. level of IL-17was highly statistically significant (P=0.002) difference between Control and Thyroiditis groups, as well as the levels of Interleukins (IL -17, IL -18 and IL -122) were higher among Hypothyroid cases of Thyroiditis group [(99.1±14.22), (149.45±13.31) and (37.80±11.89) respectively]. The Comparison of Interleukins( IL -17, and IL -18) level of Hypothyroid and Hyperthyroid among Thyroiditis group were highly statistically significant different (P=0.000 ) but level of IL -22 was no statistically significant(P=0.338 ), current study showed represented the receiver operating characteristic (ROC) curve Interleukin‎ (IL-17‎, IL-18‎ and IL-22‎) in Thyroiditis group with Control group to diagnosis Thyroiditis disorder show that the cutoff value of IL-17‎‎ was >91.17 with 83.3%sensitivity, Specificity46.7%. Also IL-17‎‎ had highly significant (P=0.000) and area under the curve (AUC) =0.807. IL-18‎‎with cutoff value>144.216 and 16.7%sensitivity, 50.0% specificity, had highly significant (P=0.000). The cutoff value of IL-22was >33.409 had significant (P=0.026) and 23.3% sensitivity, 50.0%specificity. Highest levels of IL-17; IL-18 and IL-22 among Thyroiditis group. as well as the levels of Interleukins (IL -17, IL -18 and IL -122) were higher among Hypothyroid cases of Thyroiditis groups, so IL-17‎‎ had highly significant (P=0.000) and area under the curve (AUC) =0.807. IL-18‎‎ with cutoff value>144.216 and 16.7%sensitivity, 50.0% specificity, had highly significant (P=0.000). The cutoff value of IL-22was >33.409 had significant (P=0.026) and 23.3% sensitivity,500%specificity.

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