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Abstract : Evidences had documented a causal relationship between human cytomegalovirus (CMV) infection and Bad Obstetrical History (BOH). However, a recurrent or latent CMV infection or altered immune response to CMV is resulted in recurrent pregnancy loss (RPL) is unsolved. We investigated CMV infection and antibodies to CMV after urea treatment in women with Bad Obstetric History (BOH). This case-control study was conducted on 143 women with BOH recruited to gynecology and obstetrics department clinic in Benghazi (Libya). Patients were evaluated for anti CMV IgG and IgM antibodies and IgG urea treatment using the enzyme linked immunosorbent assay method. Student’s t-test and Chi-square test were used to analyze the data. Two cases (1.4%) of positive anti-CMV IgM was detected in each group. Anti-CMV IgG positivity was more frequent in patients (39.9%. there was Big significant differences between the habitual abortion (HA) group compared to the other BOH manifestations. IgG concentration was significantly higher in HA seropositive cases than seropositive BOH patients. We found that previous exposure to CMV was significantly higher in patients with Habitual abortion than the other BOH group. Moreover, association was found between IgG urea treatment and HA. Further investigations are under way to find whether latent CMV infection starts an indirect process of autoimmune etiology in RPL or women with RPL have recurrent or reactivation of CMV infection.

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