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Abstract : Nectin-4 is a novel, highly useful biomarker for many solid cancers including breast cancer, recently gaining focus of cancer researchers all over the globe due to its potential of being a target for molecular therapy for difficult to treat cancers such as triple negative breast cancer (TNBC). Recent studies have shown that increased Nectin-4 activity is strongly connected to tumour incidence and progression in a variety of cancer types, although it is still unclear how Nectin-4 protein affects the initiation and progression of these cancers. In this review article, we have highlighted the mechanisms underlying, biological activities, and recent developments pertaining to the Nectin-4 protein expression pattern in diverse cancer types, mainly emphasizing on its role in the carcinogeneisis of TNBC. Also, we have summarised various methods of detection and scoring used by various researchers.

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