Inflammatory bowel disease (IBD) is a recurrent chronic intestinal illness categorized into two subtypes. Crohn's disease (CD) with ulcerative colitis (UC). Multiple organ systems can be affected by IBD, and pancreatic symptoms of UC are not uncommon. Numerous pancreatic illnesses are more prevalent in UC patients than in the general population. Pancreatic symptoms in UC are diverse, ranging from mild and self-limiting diseases to serious illnesses. Amylase and/or lipase levels are frequently elevated asymptomatic. In this review, the estimation of the enzyme lipase and amylase and the discussion of possible causes for the elevation can be considered as one of the most important ways to assist the specialist in diagnosing UC patients before resorting to endoscopy.