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Abstract : Stroke is a common morbid disease with high mortality, knowledge about risk factors, management, and presentations might decrease its deleterious consequences. The current study aimed to assess Perception of stroke warning signs and knowledge of potential risk factors among medical students in Tabuk University. This is a cross-sectional study conducted among 251 medical students in Tabuk, University during the period from July 2022 to September 2022. A self-administered questionnaire based on demographic data, perception of stroke, and stroke risk factors. Was used, the action to be taken for potential stroke, the medications, and gender differences were collected. Knowledge was poor regarding the definition of with no difference between females and males stroke (65.9% versus 62.1%), P-value, 0.078, 90.4% of women vs. 88.8% of men knew that hypertension is a risk factor for stroke with a not significant statistical difference, P-value, 0.683, males knowledge regarding smoking as a risk factor was higher than females (93.1% versus 80.7%, P-value, 0.003), while only 65.9% of women and 57.8% of men knew diabetes as a risk factor, P-value, 0.115. The knowledge regarding the warning signs and symptoms of stroke was sub-optimal with no statistically significant difference between females and males, P-values <0.05. The knowledge of stroke was sub-optimal among medical students at Tabuk University, Saudi Arabia, especially regarding the knowledge of diabetes and obesity as risk factors for ischemic stroke. Females' knowledge was lower regarding smoking and increasing age as risk factors. The knowledge was lower among junior students as expected. Including stroke early in the curriculum is recommended.

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