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Abstract : The rapid increase in the production of MBL and EXBL among the members of Enterobacteriaceae, primarily Klebsiella pneumoniae (K. pneumoniae), E. coli, and Pseudomonas aeruginosa (P. aeruginosa) that represent the most frequent human infection causes, is a severe global issue related to the public health. Because there are few options of the treatment for infections resulting from MBL and ESBL-producing bacteria, treating these infections can be complicated, and treatment failure is common. Regular drug resistance surveillance amongst clinical isolates will assist to determine true severity of the situation and, as a result, establish the appropriate policy for reducing the prevalence of drug resistance among bacteria. Furthermore, understanding local antimicrobial susceptibility patterns will aid in starting timely adequate preliminary treatment [1].

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