The present study aimed at the evaluation of the association between H.pylori and allergy by systematic review and meta-analysis study. We searched databases, including PubMed and Google Scholar using the following keywords in English: H. pylori& asthma; food allergy(FA); atopic dermatitis (AD) or eczema and allergic rhinitis (AR). Among 110 articles reviewed that included 40243 patients’ samples, results showed that association between H. pylori and FA was significant, while no relationship with asthma, AD and AR. The results reveal that H. pylori may be one of the main causes of allergic diseases. Thus, a novel way should be employed for the complete management of H. pylori infections.