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Abstract : Peripheral arterial disease (PAD) is a progressive disorder characterized by stenosis and/or occlusion of large and medium-sized arteries, causing obstructions in blood flow in one or more of the major limb arteries. This study was carried out evaluation the Calprotectin activity to Diagnosis of Peripheral artery disease. The samples were collected (120) individuals (both gender) (patients and control groups) with aged (30-85) years old. Sixty patients (30 Intermittent, 30 Critical) and 60 healthy controls from (February to May 2022). The present study examined levels of Calprotectin, glycosylated Haemoglobin (HbA1C), Haemoglobin (Hb), and D-Dimer. The results depicted that Hb level was significantly higher in PAD of intermittent and critical patients compared to control (12.72± 2.11mg/dL, 14.23± 2.11mg/dL and 14.84± 1.69mg/dL respectively, p < 0.001. The results showed of the HbA1c level in PAD of intermittent, critical, and controls groups were (7.37 ± 1.72%, 11.16± 1.62%, and 6.68±1.87%) respectively. The patients with the critical peripheral arterial disease (PAD) had a considerably higher HbA1c level. The present study showed of D-dimer in PAD for intermittent, critical, and controls groups that significant differences (p<0.001), recorded the highest value recorded in the critical PAD (783.96±403.94mg/mL ).The present study appeared found a significant difference (p<0.001) in different groups that calprotectin were recorded in the intermittent PAD group (1.56± 0.42 ng/ml) & the critical PAD group (1.41±0.33 ng/mL), Where they were recorded highest values in the intermittent PAD group and the lowest value in the control group (0.63± 0.08mg/mL). The data showed Elevated serum calprotectin levels in patients groups (intermittent & critical) and it correlation with HbA1C, Hb, and D-Dimer. Where suggest a role for calprotectin to the diagnosis as a biomarker for early detection of peripheral arterial disease.

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