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Abstract : Infertile males were tested for the presence of interleukin 6 and 10, as well as for the presence of lipid peroxidation in their sperm. A total of 75 men with varicoceles and 25 fertile men served as controls, with sperm samples collected via masturbation. Malondialdehyde (MDA) production in the sperm membrane was used to assess the degree of lipid peroxidation in the membrane. Statistics were used to examine the association between the quantities of interleukin-6 (IL-6) and interleukin-10 (IL-10) in plasma of seminal and lipid peroxidation levels of sperm membranes. There existed a statistically significant difference in the concentration of IL-6 in the seminal plasma of unfertile males and fertile men (p < 0.05) between the two groups. On the other hand, the concentration of interleukin-10 (IL-10) in the seminal plasma of infertile men was considerably greater than that of fertile men (p < 0.05), and the degree of lipid peroxidation in the semen of infertile men was significantly higher than that of fertile men (p < 0.05). in seminal plasma the levels of IL-6 and membrane lipid peroxidation procces in the spermatozoa were found to be positively related to each other (p < 0.05), while IL-10 levels in seminal plasma and lipid peroxidation membrane in sperm were found to be positively correlated with each other (p < 0.05). It seems that there is a potential link between plasma interleukin-10 and 6 and ranks of spermatozoa and peroxidation of fat in the sperm membrane based on these findings. It may explain the encouragement species reactive formed by sperm of males and leukocytes, which is stimulated by great ranks of IL-6. Moreover, IL-10 is categorised by chemoattractant action of both T cells and basophils, as well as by the use of a proangiogenic effect on vascular smooth muscle cells. IL-10 is a cytokine that shows a key character in a variety of inflammatory disorders.

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