About the Journal

Download [This article belongs to Volume - 140, Issue - 01]

Abstract : The number of erythrocytes, mean corpuscular volume (MCV), hemoglobin concentration, hematocrit (packed cell volume), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were the hematological parameters examined in this study. The key features of quantitative physical and functional properties of erythrocytes, as well as their correlations among people with different genotypes of the angiotensin-converting enzyme (ACE) insertion-deletion I/D polymorphism gene were investigated. The study was performed with venous blood was taken from 100 healthy female students aged 20-24 years, which was used to study the morphological and functional characteristics of erythrocytes and for the genotyping technique. The size of erythrocytes, their fullness with hemoglobin, and their osmotic resistance are all determined by genotype. When the I allele was present in the genotype, a link was found between the number of erythrocytes, hematocrit, hemoglobin content, and the stability of erythrocyte membranes. When the II genotype was present, a link was found between the number of erythrocytes, hematocrit, hemoglobin content, and the stability of erythrocyte membranes. The average volume of erythrocytes is lower in girls with the II genotype of the ACE gene, and hemoglobin saturation and osmotic resistance are higher than in girls with the D allele.

Copyright © 2020 All rights reserved | Bulletin of National Institute of Health Sciences