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Abstract : Recently, p-Coumaric acid was investigated in diabetic rats. Therefore, the purpose of this study was to determine whether p-Coumaric acid could reduce oxidative stress in diabetic rats. As a result, STZ and p-Coumaric acid were obtained from an American academic research institute in Iraq for this investigation (TAARII). The researchers induced diabetes in rats, giving STZ dissolved in buffer solution. Streptozotocin was given to the treatment group (T1) at a 25 mg/kg body weight dose for 30 days. After 30 days of treatment with p-Coumaric acid at a dose of 100 mg/kg body weight, rounded and broad seminiferous tubules with spermatozoa in their lumen were detected in male rat testes (T2). Streptozotocin and p-Coumaric acid (T3) treated animals with abnormal histopathology. Diabetic animals weighed less than control rats in T1 but more in T2 and T3. The diabetic rats gained a significant weight following a 28-day treatment with 100 mg/kg p-coumaric acid (p0.05). There were significantly more diabetic rats than non-diabetic rats. The effects of p-Coumaric acid on oxidative stress were investigated in diabetic rats using STZ and p-Coumaric acid. According to the study, p-Coumaric acid prevents blood sugar decreases. As a result, in diabetic rats, oxidative stress was decreased; therefore, p-Coumaric acid is anti-diabetic and insulin-resistance. Our research discovered that p-Coumaric acid might aid in the prevention of diabetes.

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