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Abstract : WHO declared COVID-19 as a pandemic on March 2020, rapidly after first case was discovered in Wuhan, China on December 2019. IVF centers all over the world temporarily stopped future cycles because of concerns on the possible effect of the infection on fertility and pregnancy outcomes. After the development of vaccine against SARS-COVID-19 similar concerns were raised of the possible effect of these vaccines on fertility and on the IVF outcome. This study aimed to evaluate the possible effect of mRNA vaccine on IVF parameters. A case-control observational study involving 100 couples, 50 completely vaccinated couples with two doses of "Pfizer's SARS-CoV-19 mRNA vaccine" and 50 unvaccinated couples undergoing IVF for infertility between January 2021 and June 2022. This is a multicentric research with data gathered from three centers. The number of oocytes collected, their quality, the quality of the embryos, and pregnancy rate were assessed in the two groups. The number of oocytes collected in the vaccinated group was (mean SD) 9.60±5.6 compared to (9.06 ±6.13) in the non-vaccinated group with no significant difference (P=0.647), the number of M11 oocytes was (mean SD) 6.56 ±4.2 compared to (5.63 ± 4.46) in the non-vaccinated group with no significant difference (P=0.291), and 32%pregnancy rate. There was no statistical difference in any other cycle feature or lab results. Our study found that, the "mRNA SARS-COV-2" immunization had no detectable effect on the parameters of IVF. However, further research with larger sample sizes and longer follow-up periods is required.

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