Abstract : The internet has fundamentally transformed access to health information, with many patients increasingly relying on online resources for medication guidance. This study quantitatively assesses the impact of online medication information on patient knowledge and safety. Using a cross-sectional design, data were collected through an online questionnaire distributed to a diverse sample of adult patients prescribed medications within the past year. Our findings reveal that a significant proportion of patients frequently seek medication information online, highlighting the internet's critical role in contemporary healthcare. Participants reported moderate levels of knowledge gain across key areas such as general medication information, correct usage, potential interactions, and when to seek medical help. However, substantial variability in the quality and reliability of online information raises concerns about its influence on patient understanding and safety. Notably, 61.7% of participants encountered conflicting information online, and demographic factors such as age and education level significantly influenced information-seeking behaviors and comprehension. The study emphasizes the importance of digital literacy and the role of healthcare professionals in guiding patients to credible online resources. While access to online medication information can enhance patient knowledge, it also presents challenges in discerning accurate information, particularly for populations with lower health literacy. The findings suggest that targeted educational interventions and personalized counseling can bridge the gap between information availability and effective utilization, thereby improving medication adherence and patient outcomes. This research illustrates the necessity for healthcare systems to integrate digital health literacy into patient education strategies, ensuring all patients can navigate online health information effectively. Future research should explore longitudinal impacts and develop robust frameworks for assessing the quality of online health information.