Alienation is the source of stress in organization. A person, who is alienated from organization, would not understand the concept of concentrating on time and place and this is an obstacle in coming growth in all important organizational activities. The sense of alienation will result in decrease in functions, inferior performance and increase in tardiness in doing organizational tasks the study aimed to explore the relation between work stressors and alienation among internship students. The descriptive correlation design was utilized to carry out the study. All internship students started internship in 2020 at faculty of nursing - Cairo University. Two tools were used to collect data, First tool was Work stressors assessment questionnaire, Second tool alienation assessment questionnaire consist. Finding of this study shows the highest mean percentage (78.5%) dimension for feeling of meaninglessness' dimension, while the lowest mean percentage (64%) for feeling of powerlessness dimension, the total mean percentage (68.7%) for alienation as variable and (75%) of the participants have moderate alienation level. that the highest mean percentage (88.8%) for Stressors related safety dimension, while the lowest mean percentage (78.8%) for stressors related inappropriate experience dimension., the total mean percentage (83.3%) for work stressors as variable and (54%) of the participants have high level of wok stress. there were high statistical significant differences (P=. 000) and weak statistical significant correlation between work stress and feeling of alienation. The study concluded that the internship students have moderate level of alienation and moderate level of stress, there were high statistical significant differences between work stress and feeling of alienation. Design & implement stress management programs for nursing students, educate students nurse with better stress management skill.