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Abstract : This study was conducted to investigate the adverse effect of Energy Drinks (Red Bull and C4) given to Mice in some blood and biochemical parameters which include lipids profile (HDL and LDL), Liver Function (AST, ALT, ALP, Bilirubin and Albumin), B. urea, Creatinine for kidney functions tests. The results indicated significant difference in biochemical parameters of Mice gavage by EDs (Red bull and C4); there was a significant increase (P < 0.05) in the levels of Aspartate amino Transferase (AST), Alanine amino Transferase (ALT), Alkaline Phosphatase (ALP), Bilirubin and Albumin in experimental group when compared with control group. Also it was showed a significant increase (P < 0.05) in the levels of serum creatinine and blood urea compared with control group. Finally, the results also showed a significant increase (P < 0.05) in the mean of Low Density Lipoprotein (LDL) in experimental group when compared with control group. On other hand the results also showed a significant decrease (P < 0.05) in the mean of High Density Lipoprotein (HDL) in experimental group when compared with control group.

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