Mental health issues are a concern in all societies due to their debilitating effect on an individual’s quality of life and capacity to function in society. In 2015 the prevalence of mental health problems among Malaysian adults was 29.2%; this was an increase from 10.7% in 1996. The prevalence of mental health problems is affected by many factors, including belonging to a minority population. This study aimed to evaluate the demographic factors associated with the prevalence of depression, anxiety and stress among Indian-Malaysian women. A cross-sectional study was conducted in Indian majority localities within the Klang Valley area of Malaysia in 2018 and 2019. 611 women participated by completing a self-administered questionnaire which included indices for the measurement of depression, anxiety, stress (DASS-21). The prevalence of depression in the study population was 36.2%, anxiety was 76.8%, while stress was 18%. Pearson’s Chi-Square test revealed that significant factors associated with depression were age and marital status; for anxiety significant risk factors were age, marital status, household income, education level and employment status, and for stress, the significant risk factors were marital status, household income, education level and employment. Underlying mental health issues are at a high prevalence among Indian-Malaysian women.