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Bulletin of National Institute of Health Sciences
Title : Human Papillomavirus and Epstein-Barr virus co-infection in Prostate Cancer: Observational Study
Abstract :Prostate cancer is one of the most common tumors in men worldwide, regardless of ethnic origin or demographics. It is the fifth leading cause of cancer death in men worldwide. In Africa, the disease ranks first in terms of incidence and mortality. What's more, in Morocco, the average age of prostate cancer patients is between 68 and 73. Among the many risk factors for prostate cancer, several studies have shown that specific genetic variants and viral implications are important factors in the initiation or development of prostate tumors. Recent studies have suggested that infection with EBV and HPV may also contribute to the development of this disease. However, the mechanisms by which these viruses may contribute to the development of prostate cancer are not yet fully understood. The aim of this study was to evaluate the potential role of co-infection with human papillomavirus (HPV) and Epstein-Barr virus (EBV) and their correlation with clinical and pathological parameters of prostate cancer. To achieve the objectives of these studies, a total of 100 blood samples were taken from Moroccan men with prostate cancer, after obtaining the necessary authorizations from the scientific research ethics committee. All clinical and pathological data were recorded. Extraction of genetic material according to the required protocol. The DNA samples obtained were stored for the viral applications mentioned below. A series of polymerase chain reactions and statistical analysis procedures were successfully performed. The potential viral influence on prostate cancer, previously proposed in other populations, was explored in Moroccan men. The results presented provide an overview of the main viral functions in prostate cancer in Moroccan men, and highlight the possibility of analyzing their clinical significance.
Title : The Relationship Between Infant and Child Feeding History and Stunting Prevention in Toddlers Aged 24–59 Months in The Work Area of Bukit Kerman Health Center, Kerinci District, Jambi Province
Abstract :Stunting is a problem of chronic malnutrition due to lack of nutritional intake from birth to the age of two. Of the 11 districts in Jambi, Kerinci Subdistrict is recorded with the second highest prevalence of stunting in toddlers aged 24-59 months, which is 26.7%. A very important factor in the incidence of stunting is the rate of exclusive breastfeeding and adequate nutrition. A case control study, with purposive sampling technique and obtained 184 samples (46 cases and 138 controls), based on sex matching. The independent variables were history of initiation of early breastfeeding, exclusive breastfeeding, and practice of giving complementary feeding (time, frequency, amount, type of basic ingredients, and variety of nutrients), while the dependent variable was the incidence of stunting. Data analysis was performed by Chi-Square and Enter logistic regression method. There was a significant relationship between the history of early initiation of breastfeeding and the practice of giving complementary feeding with the incidence of stunting. The factors that contributed the most were the type of basic ingredients (p=0.004; OR=22.545), the amount (p<0.001; OR=8.115), the variety of nutrients (p=0.006; OR=7.512), and the frequency of complementary feeding (p=0.017; OR=5.059). In preventing stunting it is important to pay attention to the type of basic ingredients used with attention to the nutrients contained. In addition, the frequency and amount are also important to note according to the age of the toddler.
Title : Policy Implementation Analysis of Diabetes Mellitus Referral System in Kassi-Kassi Health Center Makassar City
Abstract :The prevalence of diabetes mellitus worldwide continues to increase, it is predicted that in 2030 people with diabetes mellitus will reach 550 million people, this is equivalent to about three new cases every 10 seconds, or nearly 10 million year. The epidemic is not evenly distributed around the world. While the world-wide prevalence of diabetes is 3–4%, several countries and regions experience a prevalence rate of diabetes of well over 10%. This research method uses a qualitative descriptive method. The total number of samples in this study are 7 people consisting of 6 key informants and 1 additional informant. The method of data collection in this study uses the interview method. The results of the study found that the implementation of the referral system policy went as expected, it can be seen in terms of aspects of communication that are going well, sufficient resources, good disposition and a clear bureaucratic structure. However, there are some of things that still need to be improved, such as outreach related to the flow of the referral system for patients with diabetes mellitus. Based on these results, it can be concluded that the policy implementation of the referral system at the Kassi Health Center has been going well and as expected. The community is expected to always follow the latest information related to the referral system, especially people with diabetes mellitus so that the current referral flow is still implemented. This information can be obtained through applicable guidelines, the internet or direct discussion.
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