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Bulletin of National Institute of Health Sciences

Journal ID : BNIHS-13-03-2022-10183
Title : Effect of Folic Acid on Blood Picture in Female Rabbits Treated Experimentally with Methotrexate
Abstract :

Methotrexate (MX) is a drug with multiple physiological effects on the body. The objective of this search is to evaluate the enhancing action of folic acid on the blood profile of MX-treated rabbits. 30 female rabbits were divided into 3 groups and each group consisted of 10 animals. CON group, which included healthy rabbits, did not receive any treatment, while the MX group included animals which were injected intraperitoneally with methotrexate once a week. Finally, FO-MX rabbits received a combined dose of oral folic acid with methotrexate. The duration of the experiment lasted 4 weeks and after completion the animals were slaughtered and the marrow was collected. The results demonstrated that MX caused megaloblastic anemia which was characterized by erythroid hyperplasia, megaloblastoid polychromatophilic rubricytes, macromyelocytes and meta-myelocytes. While the FO-MX group showed a good prognosis and improved health. We concluded that co-administration of FO with MX ameliorated the adverse changes of MX, so we recommend that further studies be conducted to evaluate and understand the mechanism of effects of these drugs against the toxicity of the MX.

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Journal ID : BNIHS-13-03-2022-10182
Title : Assessment of Serum NGAL, Procalcitonin in Patients with Large Recurrent Renal Stone and Primary Renal Stone
Abstract :

Neutrophil gelatinase-associated lipocalin (NGAL) is a which is extensively increased in the serum or urine of patients within a few hours after ischemia. Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the PCT levels are marker for determine if a patient has an infection. This Cross-sectional Study was designed under the supervision of College of Medicine, Almustansiriya University, Chemistry and Biochemistry Department. A eighty five 85 patients had stone size greater or equal to 1.5 cm for (45 Male,40 Female). Serum NGAL, PCT levels in primary renal stone group was significantly lower than of secondary renal stone group. p ≤0.0001, AUC for Serum NGAL, 0.990, the cut off value was 194.50, (AUC) for serum PCT, was 1.000, cut off value was 3.950(ng/ml). Serum NGAL and serum PCT were significantly higher in recurrent renal stone than primary renal stone when renal stone size ≥1.5 cm. Considered as serum NGAL, and PCT in both of primary renal stone group and secondary renal stone group were a perfect markers for predicting Renal stone disease in patients with acute kidney injury.

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Journal ID : BNIHS-13-03-2022-10181
Title : The impact of Body Mass Index on Spirometric Parameters among a Sample of Population
Abstract :

Obesity represents one of the major health problems of modern life and directly affects respiratory mechanics. So the objective of this study is to detect the impact of body mass index (BMI) on spirometric parameters among a sample of the adult population in Egypt and to detect which of the spirometric parameters is majorly affected. We retrospectively included 80 participants > 18 years old with normal pulmonary function (forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) > 80% and forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC)> 70% of predicted) visiting Ain Shams University hospital, between March 2019 and October 2019 then they were divided into 3 groups according to the BMI. Statistical significant decrease in FVC, FEV1, FEV1/FVC %, and FEF 25 -75 % were found as BMI increases and there was a negative correlation between BMI and spirometric parameters.

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Journal ID : BNIHS-13-03-2022-10180
Title : Nurses' Knowledge and Practice toward Post Cardiac Catheterization Patients' Safety
Abstract :

To determine a nurse's knowledge of patient safety following diagnostic procedures Cardiac Catheterization at Al-SADER Teaching Hospital in Basra City. From the 5th of November, 2020, to the 25th of February, 2021, a descriptive study was carried out. The study's sample was chosen using a non-probability (purposive sampling) method. The study includes thirty (30) nurses from Al-Sader Teaching Hospital in Basra City who work in the medical ICU and cardiac medical ward. A self-structured questionnaire was used to examine the knowledge and practice of nurses working in intensive care units and cardiac medical wards. Descriptive statistics were used to analyze the data (frequencies, percentages, mean, Likert score). Out of 30 participants, 86.6 percent were females, and With age groups ranging from 20 to 29, the majority of nurses had 1-10 years of experience. The mean of total knowledge was found to be good when contrasted to the poor mean of practice. This demonstrated that nurses are well-versed in post-cardiac catheterization complications. In terms of patient safety following cardiac catheterization, there is a positive relationship between knowledge and practice. Nurses with the necessary knowledge and experience can assist inpatient rehabilitation. The study suggests that educational training programs for nurses who work in cardiac catheterization be implemented, that nursing faculty pay more attention to cardiac catheterization and patient safety following cardiac catheterization and that postgraduate studies specializing in cardiac catheterization nursing be established.

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Journal ID : BNIHS-13-03-2022-10178
Title : Long-term effects of percutaneous balloon mitral valvuloplasty on left atrial function
Abstract :

Balloon mitral valvuloplasty (BMV) has been the procedure of choice for patients with significant mitral stenosis. It was suggested that successful BMV reduces the size of the left atrium and improves left atrial function in patients with MS. The purpose of this study was to evaluate long-term effects of BMV on left atrial function. The study included 70 patients with mitral stenosis who underwent BMV 1 year or more before and were coming for routine follow up echocardiography post BMV at Ain-Shams university hospital. Catheterization data and echocardiographic data of the patients before and immediately after BMV were retrospectively collected and compared to the echocardiographic data obtained at the follow up, one year or more after BMV. The mean age of this study group at time of procedure was 34.7 ± 12.08 years. The majority of the study were females representing 75.71% of the cases. BMV resulted in an immediate significant improvement of mitral valve area, mean transmitral pressure gradient and right ventricular systolic pressure with an immediate marked improvement in all LA diameters, areas, volumes and LA function. At the long-term follow up, the results have shown a significant improvement of LA function index (LAFI), LA end systolic volume (LAESV) with the indexed volume (LAESVI) and LA transverse diameter, in comparison to immediately post BMV results. BMV has good immediate and long-term results leading to a significant improvement of LA volumes and function.

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