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Bulletin of National Institute of Health Sciences

Journal ID : BNIHS-05-03-2022-10154
Title : Measurement of maternal serum interleukin-33 level for the diagnosis of placenta previa accrete
Abstract :

Placenta previa accreta is a life-threatening obstetric condition that is responsible for massive obstetric hemorrhage that is a leading cause of pregnancy-related death. Interleukin-33 is associated with the invasion, proliferation, and metastasis of various cancers. The trophoblast of the placenta previa accreta invades into the myometrium in a similar way to the invasion of cancers. We studied the role of interleukine-33 in placenta previa accreta as a biomarker for antenatal diagnosis. To determine the usefulness of serum Interleukin-33 as a sensitive biomarker of invasive placentation. Prospective cohort study, in the department of Obstetrics and Gynecology at Al-Yarmouk-Teaching Hospital. This study included 90 cases of pregnant women divided into 3 groups, (group 1) 20 pregnant women diagnosed to have placenta previa accreta (group 2) 30 pregnant women diagnosed to have placenta previa nonadherent, and (control group3) which comprised of 40 pregnant women with the normal placenta. Serum samples were collected for both groups to measure Interleukin-33 levels by ELIZA method then statistical analysis was performed to detect the association between the interleukin-33 concentration and placental invasion. The result of the present study showed that serum interleukine-33 was significantly higher in placenta previa accreta patients when compared with placenta previa non-adherent and control group with a p-value = 0.001 and the interleukin-33 in cases who require urologist interventions and bladder repair was significantly higher p value=0.001and interleukine-33 level was also higher in cases which revealed percreta by histopathological reports than in cases of increta and accreta with p value=0.001. Higher levels of maternal serum IL-33 have been linked to placenta previa accreta, and greater levels in patients with percreta compared to increta and accreta show that IL-33 may play a role in aberrant placental invasion.

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Journal ID : BNIHS-02-03-2022-10152
Title : Follow up memory T and B cells in Iraqi COVID-19 recovered patients
Abstract :

Corona Virus Disease 2019 (COVID-19) globally a main healthcare threat, so it is important to understanding the role of humoral and cellular immune response in this disease. Follow up memory markers expression of T cell (CD3+CD45RO+CD62L+) and B cell (CD19+CD27+) in COVID-19 recovered patients for six months and correlation the level expression markers of memory T and B cell with severity. Also how long memory cell remained to provide protection against re-infection in COVID 19 recovery patients. The nasopharyngeal swab was use to confirm recovery via Real-Time Polymerase Chain Reaction (RT-PCR) technique. Cluster of Differentiation (CD) marker of memory cell count in peripheral blood via flowcytometry technique. Highest percent of COVID-19 recovered patients age groups is age group 30-39 (31.4%), Male have highest percent cases (62.9%) than female (37.1%). A significant decrease in CD3 P=0.0001 (P≤0.05) in studied recovered patients groups (G1, G2, G3 & G4) as compared with control group. In addition there is a significant differences within studied groups. A significant differences in CD3+CD45RO+, CD3+CD45RO+CD62L+ cell P=0.033, P=0.004 (P≤0.01) in studied groups as compared with control group. Finally, there is a significant differences P=0.001, P=0.024 (P≤0.05) between severity sub groups in G1, G2. Regarding B cell markers CD19, a significant increase P=0.021(P≤0.05) in studied recovered patients groups (G1, G2, G3 & G4) as compared with control group, also a significant differences within studied groups. A significant increase P=0.010 (P≤0.05) in CD19+Cd27+ of studied groups (G1, G2, G3 & G4) as compared with control group. Finally, a significant differences P=0.0001 (P≤0.01) between severity sub groups in G1, G2, G3 and G4. There were decreases CD3+ cell in recently COVID-19 recovered patients other markers CD45RO+ CD62L+ on CD3+ cell shown increase in peripheral blood T cell of COVID-19 recovered patients. Increase in the number of CD19+D27+ B cells. In addition CD3+ cell and CD19+ cell is correlated with COVID-19 severity.

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Journal ID : BNIHS-28-02-2022-10150
Title : Evaluating Some Biochemical Parameters in Pregnancy Women with COVID-19 Infection
Abstract :

Coronavirus infection (COVID-19) is a global public health issue at the present. However, previous research on the results of COVID-19 blood tests in pregnant women is inadequate. the goal of the study: The goal of this study was to study some biochemical tests in pregnant women in Mosul, Iraq, who had COVID 19 infection. A case-control research involving 331 pregnant women (113 with COVID-19, 110 without COVID-19, and 108 healthy non-pregnant women) who paid to visit a private laboratory in Mosul, Iraq from the date of 15/11\2021 to 15/1 2022. All patients have already been diagnosed with COVID-19 and they have symptoms and signs. Each of the patients and healthy controls had their whole blood samples collected to be analyzed for; serum ferritin, GOT, and GPT. Also analyze lipid profile as Total cholesterol, T.G, HDL-c, LDL-c, and VLDL-c. The large percentage of pregnant women with Covid-19 had greater levels of serum ferritin, ALP, and lipid profile than pregnant women without Covid-19, according to the current study. In addition, pregnant women who had Covid-19 had lower serum GOT and GPT levels than pregnant women who did not have Covid-19. Infections with Covid-19 may elevate the levels of serum ferritin, ALP, and lipid profile. As a result, it's necessary to keep a check on these biochemical parameters, especially in those who have severe Covid-19 infection.

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