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Bulletin of National Institute of Health Sciences

Journal ID : BNIHS-09-04-2022-10250
Title : Structure and magnetic properties of Zn-Mn-Fe2O4 prepared by Sol-Gel method
Abstract :

In order for the nanomaterials to be utilized, it is vital to be able to control the structural and magnetic properties of the Mn-Zn-ferrites nanocomposite by sol-gel nanocomposite generated by sol – gel method at 650, 750, and 850 oC. An examination into the possibility of producing the Mn-Zn-ferrites (NPs) by sol-gel as prospective structure-tunable nanomaterials is described in this report. X-ray diffraction (XRD), field emission-scanning electron microscopy (FE-SEM), Fourier-transform infrared (FTIR) spectroscopy and Vibrating Sample Magnetometer (VSM) analysis were used to characterize the structural and magnetic properties of the Mn-Zn-ferrites by sol-gel. The crystallite sizes range from 15 to 18 nm, and the cubic structure of the ferrites shows up in XRD (NPs). Nanoparticles having a particle size of 27.77 to 72.04 nm were found in the produced Mn-Zn-ferrites. In the case of the Mn-Zn-ferrites, prominent FT-IR absorption peaks at 400 and 500 cm-1 indicated the presence of Fe-O, Mn-O, and Zn-O vibrational bands. Results from the VSM demonstrated that the magnetic nature of materials changed dramatically from pristine as magnetization rose and coercivity decreased with Mn-Zn-ferrites nanoparticles. Finally, an optimal magnetic parameter value (Ms =0.80 emu/g and Hc =75 Oe) at (850) oC was obtained from the data.

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Journal ID : BNIHS-08-04-2022-10249
Title : Effects of Gestational Age on Resistance Index, Pulsatility Index, and Peak Systolic Velocity of the Umbilical and Middle Cerebral Arteries in Healthy and Hypertensive Pregnant Women
Abstract :

Doppler ultrasound provides information on the different aspects of blood flow, such as flux, direction, speed, volume, and impedance. The aim of the present study is to find the effects and the reference ranges of hypertension on blood flow of pregnant women. The study was conducted on 117 pregnant women. The data recorded via routine Doppler measurements at 14-40 weeks of gestation. The study group was divided into two groups: healthy pregnant in category (1) and pregnant with hypertension in category (2). A strong negative correlation was between gestational age (GA) and the resistive index of the middle cerebral artery (MCA-RI) from the 14th to the 28th weeks. A strong positive correlation was between MCA (Pulsatility index (PI) and RI), and was between umbilical artery UmA (RI and PI) with gestation period in both groups. A negative linear correlation was between peak systolic velocity (PSV) and RI. The parameters measured of hypertension showed that they have effects on blood flow and can be considered as the reference ranges of hypertension for blood flow of pregnant women.

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Journal ID : BNIHS-08-04-2022-10248
Title : The Effect of Repaglinide on the Liver and Kidney Histology of alloxan induced diabetic albino rats
Abstract :

The antihyperglycemic medication Repaglinide (RG) is used to treat non-insulin-dependent diabetic mellitus., that stimulates insulin release from pancreatic beta cells by binding to and ultimately activating ATP dependent potassium channels. The purpose of this study was to investigate the protective effect of Repaglinide on liver and kidney tissue of diabetic albino rats that had been induced by alloxan. In this investigation, 20 male white adult albino rats were separated into two groups (10 rats) were applied to produce diabetes mellitus (type II) using alloxan monohydrate, and the second group (10 rats) were administered normal saline intraperitonealy. These animals were divided in to four groups: Group 1 Normal control non-diabetic rats were only administrated distilled water; Non-diabetic rats in Group 2 were given 4 mg/kg/day of repaglinide; Group 3 Diabetic control who were given alloxan i.p. and administrated distilled water orally but were not given any medications; Groups 4 Diabetic rats treated with repaglinide 4mg/kg/day. According to the histological sections all of non-diabetic control, non-diabetic rats treated with repaglinide and in diabetic rats treated with repaglinide had normal histology of the liver and kidney, whereas diabetic control had hepatocytes degeneration and lymphocyte infiltration in both liver and kidney. On the other hand, rats treated with repaglinide showed a noticeable recovery of liver and kidney tissues, suggesting that (RG) might be a useful treatment for treating and avoiding harmful alterations in these tissues.

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Journal ID : BNIHS-08-04-2022-10247
Title : Virulence of variant wild and stressed Aspergillus fumigates strains: novel studies on mice model
Abstract :

Invasive aspergillosis remains a severe fungal disease with high mortality. In this study, we isolated variant strains of Aspergillus fumigates from different sources, then those strains were stressed through exposing to ultraviolet radiation(UV). Moreover, these wild strains allowed to grow on nutrient deficient media and also the variants incubated at different temperatures (15°, 25°,45°C) .After that we developed intranasal mice model of invasive pulmonary aspergillosis (IPA), in which groups of mice immunosuppressed by cortisone acetate then mice divided into groups in which some groups for infection by the wild isolated strains ,other for infection by the stressed strains .Depending on mean cut off value for serum galactomannan test ≥.5 ODI, the GM antigenemia of serum from mice group infected with wild variant strains was positive in 16/20 tested samples (78%) with considerable variation of GM- index (ODI. 61: 2.39), also lung tissue from these mice showed positive growth culture with fungal invasion and obvious lesions using PAS staining .On the other hand , the GM index of serum from mice group infected with UV exposed variant strains and strains grown on nitrogen & carbon deficient media tested negative GM test with ODI < .5, also fungus not recovered from their lung tissues during culture .Serum samples of the mice group infected with variant strains incubated at 25°C and 45°C tested positive with varied ODI, and lung tissue from these mice showed positive growth culture with lesions using PAS staining .Our conclusion from that results was that the stressed strains showed difference on virulence in comparison to the wild isolated strains.

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Journal ID : BNIHS-07-04-2022-10246
Title : Nomophobia, daytime sleepiness, and Chrono nutrition among medical students in Tabuk City, Saudi Arabia
Abstract :

Nomophobia might be hazardous for medical students in terms of academic performance, accidents due to loss of concentration, and poor social relationships. This study aimed to assess nomophobia, excessive daytime sleepiness, sleep habits, and meal timing among medical students in Tabuk. A cross-sectional descriptive study was conducted among the clinical phase medical students in Tabuk City Saudi Arabia during the period from January to April 2021. A structured questionnaire based on demographic data, sleep and wakeup time and sleep duration during the working days and weekends, subjective sleepiness during class sessions, and using the phone during lectures, labs, and clinical rounds, and nomophobia questionnaire was used. The frequency of breakfast skipping and late dinner consumption and sleep latency was also recorded. Out of 111 students (98.2% were homophobic and 89.2% reported excessive daytime sleepiness), breakfast skipping was found in 44.1%, late dinner intake in 64.8%), while 89.2% used their phones during class sessions. Daytime sleepiness was associated with chronotype (P<0.05), no association was found with BMI, nomophobia, and breakfast skipping (P>0.05). Nomophobia, subjective daytime sleepiness, using mobile phones during lectures, and inappropriate meal and sleep timing were common among medical students in Tauk City, Saudi Arabia. Chronotype was associated with daytime sleepiness, no association was evident regarding other factors. Larger multi-center studies assessing the sleep and meal pattern (Chrono nutrition) and nomophobia effects on academic performance are needed.

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