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Bulletin of National Institute of Health Sciences

Journal ID : BNIHS-07-04-2022-10245
Title : Relationship between Allergy and Helicobacter Pylori
Abstract :

The present study aimed at the evaluation of the association between H.pylori and allergy by systematic review and meta-analysis study. We searched databases, including PubMed and Google Scholar using the following keywords in English: H. pylori& asthma; food allergy(FA); atopic dermatitis (AD) or eczema and allergic rhinitis (AR). Among 110 articles reviewed that included 40243 patients’ samples, results showed that association between H. pylori and FA was significant, while no relationship with asthma, AD and AR. The results reveal that H. pylori may be one of the main causes of allergic diseases. Thus, a novel way should be employed for the complete management of H. pylori infections.

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Journal ID : BNIHS-07-04-2022-10244
Title : TPGS in drug delivery systems and pharmaceuticals of veterinary and human applications
Abstract :

The FDA has approved D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) as a safe pharmacological adjuvant, and many drug delivery procedure rely on TPGS have been designed.TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, vaccine system adjuvant, nutritional supplement, film plasticizer, anticancer reagent, and so on, are discussed in this review. Consequenly, TPGS can inhibit P-glycoprotein dependent on ATP and act as a robust excipient that promotes the efficiency of delivery and the therapeutic effect of drugs. Inhibition of P-gp occurs through mitochondria-dependent inhibition of the P-gp pump. Many of the latest studies address the use of TPGS for many permeable drugs as well as less soluble medication in the manufacture of nanodrugs or other formulations. Nevertheless, it has been confirmed that TPGS shows a robust improvement in chylomicron secretion at low concentrations and improves intestinal lymphatic transport, which would also boost the potential of drug absorption. It also indicates that there are still many problems facing clinical translation of TPGS-based nanomedicines, requiring a more deep evaluation of TPGS properties and a future-based delivery method.

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Journal ID : BNIHS-05-04-2022-10240
Title : Changes in oral health attitude and behavior of undergraduate Iraqi dental students
Abstract :

The present study was aimed to evaluate the changes in the oral and dental health attitudes and behaviors of the dental students in the city of Baghdad/ Iraq during their dental study courses. A self-assessment 16-item survey questionnaire was distributed among 659 students at different dental study stages. The samples were taken from the Dental Faculty, Al-Rafidain University College, Baghdad. Totally 396 pre-clinical (1st, 2nd and 3rd stages of dental collage) and 263 clinical students (4th and 5th stages of dental collage) with a mean age of 18-24 participant in this study. The questionnaire formula involved 3 demographic questions and 13 questions on the dental attitudes and behaviors of the students. The statistical analysis in this study was based on Chi-square and logistic regression models. The average score of the 4th and 5th stage students was higher than that of the 1st, 2nd and 3rd stage students remarkably. Statistically remarkable differences were present between the (1st, 2nd and 3rd stages) and the (4th and 5th stages) dental students for using dental floss and mouthwash regularly, presence of untreated carious teeth, smoking habit, deciding the treatment they need, gum bleeding on brushing, seeking dental visits and dental health rating. The results of this study showed the relatively improved oral and dental health attitudes of Iraqi dental students throughout their study years. This study confirmed that the overall oral health attitudes and behavior of Iraqi dental students was good and improved with rising level of education. However, there were deficits in few areas which require extra concerning and more properly established oral and dental health educational programs to rise the students’ behavior towards oral health.

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Journal ID : BNIHS-04-04-2022-10239
Title : The Relationship between Work Stressors and Alienation among Internship Students
Abstract :

Alienation is the source of stress in organization. A person, who is alienated from organization, would not understand the concept of concentrating on time and place and this is an obstacle in coming growth in all important organizational activities. The sense of alienation will result in decrease in functions, inferior performance and increase in tardiness in doing organizational tasks the study aimed to explore the relation between work stressors and alienation among internship students. The descriptive correlation design was utilized to carry out the study. All internship students started internship in 2020 at faculty of nursing - Cairo University. Two tools were used to collect data, First tool was Work stressors assessment questionnaire, Second tool alienation assessment questionnaire consist. Finding of this study shows the highest mean percentage (78.5%) dimension for feeling of meaninglessness' dimension, while the lowest mean percentage (64%) for feeling of powerlessness dimension, the total mean percentage (68.7%) for alienation as variable and (75%) of the participants have moderate alienation level. that the highest mean percentage (88.8%) for Stressors related safety dimension, while the lowest mean percentage (78.8%) for stressors related inappropriate experience dimension., the total mean percentage (83.3%) for work stressors as variable and (54%) of the participants have high level of wok stress. there were high statistical significant differences (P=. 000) and weak statistical significant correlation between work stress and feeling of alienation. The study concluded that the internship students have moderate level of alienation and moderate level of stress, there were high statistical significant differences between work stress and feeling of alienation. Design & implement stress management programs for nursing students, educate students nurse with better stress management skill.

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Journal ID : BNIHS-04-04-2022-10238
Title : Association of ABO genotype and phenotype with Angiotensin Converting Enzyme (ACE) and Angiotensin II levels in hypertensive patients on Candesartan treatment
Abstract :

Hypertension is a major modifiable cardiovascular risk factor that is affecting more individuals globally. In addition to poor treatment adherence, genetic diversity may be linked to pharmacological efficacy. In family genetics, heritability of blood pressure ranges from 30% to 50%. Antihypertensive treatment response is genetically variable. Candesartan is frequently utilized as a first-line therapy for hypertension patients, regardless of therapeutic efficacy, which reveals interindividual variability in hypertensive patients. It depends on the ABO gene polymorphism and blood group. Angiotensin II (ACE) elevates blood pressure. In the Kerbala'a province, we look into ACE activity and candesartan responsiveness. The study comprised 92 hypertension patients taking 8 mg candesartan once day. ACE, angiotensin II, blood type, blood pressure, and heart rate were all tested. The genetic variant ABO (T>G) rs495828 strongly affects ACE levels in hypertensive patients. For patients with high ACE and angiotensin II levels, candesartan is a viable choice, but it is not for those with low levels.

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