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Bulletin of National Institute of Health Sciences

Journal ID : BNIHS-11-04-2022-10257
Title : Isolation and identification of internal parasites of quails (Coturnix coturnix) in some areas of Salah El-Din Governorate
Abstract :

Through this study, approximately 100 quail birds are collected from November 2020 to June 2021 from Salah El-Din Governorate and dissected to investigate internal parasites from quail birds which are tapeworms such as and Diorchis. Sp, Raillietina echinobothride, as well as nematodes Ascaridia columbae, Ascaridia hemaphrodita and Capillaria columbae with different rates. The highest infestation recorded is in tapeworms in the genus Diorchis. Sp by 23%, while in nematodes the highest infection rate is recorded in the genus Ascaridia hemaphrodita by 21% in quails. The results of the study also show that the highest rate of infection of quail with internal parasites is recorded in May / 2021 with a rate of 26.0% following that during June / 2021 by 22.1%. The lowest rate is recorded in November and December 2021/ and January 2022 by 0.0%. The relationship reached by the results of measuring the rate of infection in quail birds with weight is an inverse relationship between the weight of the bird and the rate of infection, as the higher the infection rate, the lower the weight.

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Journal ID : BNIHS-10-04-2022-10254
Title : Cutaneous T-Cell Lymphoma - Review Of Literature With Reference To A Case Report
Abstract :

Cutaneous T cell lymphomas (CTCL) are a diverse group of extranodal non-hodgkin's lymphomas defined by a skin infiltration of neoplastic monoclonal T cells. Adults between the ages of 55 and 60 are most commonly affected, with a yearly incidence of roughly 0.5 per 100,000. The most frequently occuring subtypes of CTCL include mycosis fungoides, Sézary syndrome, and primary cutaneous peripheral T cell lymphomas not otherwise specified (PCTCL-NOS). CTCL is a difficult disease to understand in terms of etiology, pathogenesis, diagnosis, treatment, and clinical outcome. In this paper, we give a case study and highlight the progress made in these sectors.

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Journal ID : BNIHS-09-04-2022-10253
Title : MEASUREMENTS OF DENTAL BONY LANDMARKS USING CONE-BEAM COMPUTED TOMOGRAPHY AMONG THE IRAQI POPULATION
Abstract :

The mental foramen (mf) is a strategically significant landmark; to avoid mental nerve damage, its location, morphology, and anatomical variances must all be evaluated before operation. The mental foramen is a complicated region with several anatomical peculiarities. The nerve can be damaged in various ways, including endodontic treatments and overfilling, tooth extractions, and surgical procedures such as implantology; it can result in temporary sensitivity symptoms comparable to labiomental paresthesia. CBCT enables the collection of detailed information on the mf anatomy, its surroundings, and anatomical changes that may occur when clinical factors such as sex, side, or dental status change. When two-dimensional and three-dimensional images were compared, several differences were discovered. The average distances observed with cbct between the mf and the midline and between the mental foramina were larger than those assessed with pan. CBCT was used to determine the locations of the mental foramen and their relationship to the mandibular posterior teeth and the thicknesses of the cortical plates of lower premolars and molars teeth.

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Journal ID : BNIHS-09-04-2022-10252
Title : The impact of some processing and formulation on dissolution rate of aspirin in different dosage form
Abstract :

Most studies had been used dissolution test since it is one of the most important quality control tests performed on pharmaceutical dosage forms and is now developing into a tool for predicting bioavailability, and in some cases, replacing clinical studies to determine bioequivalence. Dissolution behavior of drugs has a significant effect on their pharmacological activity. In fact, a direct relationship between in vitro dissolution rate of many drugs and their bioavailability has been demonstrated and is generally referred to as in vitro-in vivo correlation, IVIVC. In an attempt to study the possible changes that can improve the bioavailability of aspirin, decrease gastric side effect and provide a rapid effect in our study, we tried to collect many researches and benefit from previous experiences. Practical plan of the study was designed, and dissolution test was the corner stone of our plan. The study path was changed during COVID-19 pandemic existence to a theoretic review. The study is designed in a way to explore, in a comparative manner, the impact of excipients and dosage form formulations on aspirin’s dissolution rate and aimed to provide prospective studies with the required information that mirror the effect of formulation changes on the in vivo performance via dissolution studies.

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Journal ID : BNIHS-09-04-2022-10251
Title : The Role Of Dissolution Test in Evaluation Of Ibuprofen Oral Dosage Form Availablein Iraqi Market
Abstract :

The aim of this study was to assess the quality of some selected ibuprofen products in community pharmacies in Iraq. Different parameters of quality control of pharmaceutical products can guarantee the quality and bioavailability and optimal therapeutic activity. Used quality control parameters, i.e., the variation of weight, friability, disintegration time, dissolution time were tested in vitro. The weight range was (0.56-0.60) g, (0.26-0.33) g, (0.48-0.54) g for Apifen (Ajanta) (400), Apifen (Ajanta) (200), and ibuprofen (flamingo) (400) respectively. Disintegration time was (18min, 17min, and 13min) for Apifen (Ajanta) (400), Apifen (Ajanta) (200), and ibuprofen (flamingo) (400) respectively. Dissolution time at 0.1 N HCL 12.9, 12.2, 18.5, For Apifen (Ajanta) 200 mg, Apifen (Ajanta) 400mg, Ibuprofen 400mg and the dissolution time at Phosphate buffer pH6.8 88.7, 86.6, 90.2 Apifen200mg, Apifen 400 mg, Ibuprofen 400mg. The results showed that all products fulfill the given specification of pharmacopeia (USP-NF) which its dissolution rate was less % in USP (85%after 30min) in phosphate buffer and in 0.1N HCL (18% after 30 min) for ibuprofen(flamingo). Disintegration of ibuprofen 400(flamingo) showed the quickest disintegration while Apifen (400) the slowest.

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